(Enlaibao) Enramycin Introduction
Enramycin is obtained by fermentation of actinomycetes. It is a polypeptide antibiotic that combines unsaturated fatty acids with more than a dozen amino acids. The main components are enramycin and , is used in its hydrochloride form. White or slightly yellowish-white powder (the crude product is gray or gray-brown powder with a special odor). ~℃ Decomposition
Enramycin has strong activity against Gram-positive bacteria, especially against harmful Clostridium in the intestine. It is not easy to develop resistance after long-term use. Because it changes the bacterial population in the intestine, it has a good utilization effect on the nutrients in the feed. It can promote weight gain of pigs and chickens and improve the feed conversion rate.
Mechanism of Action
Pharmacodynamic Study
Enramycin has a strong effect on Gram-positive bacteria. The main mechanism is to inhibit the synthesis of bacterial cell walls, causing cell wall defects and leading to intracellular penetration. When the pressure rises, extracellular fluid penetrates into the bacteria, causing the bacteria to deform, swell, rupture and die. Enramycin mainly acts on the fission stage of bacteria, not only sterilizing but also lysing. Enramycin has strong antibacterial activity against harmful pathogens such as Clostridium, Streptococcus, Staphylococcus, and Pneumococcus in the intestine.
Toxicological Studies
Enramycin has very low toxicity. Acute toxicity experiments show that enramycin is actually non-toxic when administered orally, subcutaneously or intramuscularly. Enramycin has no mutagenic or teratogenic effects. Target animal safety study results show that oral administration of enramycin is safe.
Drug Residues
Residue experiments show that after intramuscular injection of enramycin, the drug concentration in the blood reaches the peak value, and then gradually decreases, and a considerable amount of the drug is still present in the blood. Because drugs that enter the body are excreted slowly, remain in tissues for a long time, and have adverse effects on liver and kidney functions, and can cause inflammatory reactions such as pain, redness, and swelling at the injection site, oral administration is used in clinical practice and injection is prohibited.
Enramycin is extremely difficult to absorb when taken orally, and the drug is mainly excreted through feces. Relevant experimental results show that after animals take enramycin directly, the concentration of enramycin in the blood is lower than the detection limit (/). Drug residues in any tissue of broiler chickens or pigs were below the detection limit (/).
Advantages and characteristics of Enlaibao Enramycin
) Adding a small amount of enramycin to the feed can promote growth and significantly increase feed returns.
) Enramycin can show good antibacterial effects against Gram-positive bacteria under both aerobic and anaerobic conditions. Enramycin has a strong effect on Clostridium perfringens, which is the main cause of growth inhibition and necrotizing enteritis in pigs and chickens.
) There is no cross-resistance to enramycin.
) Enramycin resistance develops very slowly, and no Clostridium perfringens resistant to enramycin has yet been isolated.
) Because enramycin is not absorbed in the intestine, there is no need to worry about drug residue and there is no withdrawal period.
) Enramycin has stable performance in feed and remains active even during the processing of pellets.
) Enramycin can reduce the occurrence of loose feces in chickens.
) Enramycin can inhibit ammonia-producing microorganisms, thus reducing the ammonia concentration in the intestines and blood of pigs and chickens, thereby reducing the ammonia concentration in the livestock house.
) Enramycin can reduce the clinical symptoms of coccidiosis, probably because enramycin has a strong inhibitory effect on anaerobic bacteria in secondary infections.
, Our company's enramycin product Enlaibao
Enlaibao is an enramycin premix developed and produced by Shanxi Xinyuan Huakang in cooperation with scientific research institutions such as the Chinese Academy of Sciences.
Recommended use of Enlaibao (enramycin) in chicken feed
Used throughout the entire process of commercial broilers
Day age (chick stage) Enlaibao/ton
Day age (young chickens) Stage) Enlaibao/ton
From day to slaughter (rearing stage) Enlaibao/ton
In the middle and chick stages, the anti-coccidial drugs Hainanmycin, monensin and salinomycin are used.
Broiler breeders
From week to week, when changing the feed for young chickens, add Enlaibao/ton of full price feed, for consecutive days
From week to week, when changing to the feed for peak egg production, add Enlaibao/ton Full price feed, continuous use for days
During the egg laying period of laying hens, Enlaibao/ton full price feed.
Application of Enlaibao (enramycin) in pig feed
Enramycin mixture can promote growth and improve feed return for both piglets and finishing pigs. According to statistics, adding enramycin to feed can increase the weight of pigs and increase the feed conversion rate.
Recommended use of Enlaibao in pig feed
Full price feed for suckling piglets is being used to prevent diarrhea and promote growth
Enlaibao/ton + salinomycin/ton
Enlaibao/ Ton + antimicrobial/ton
Enlaibao/ton, can be used alone
Use full price feed for sows
Prevent sow flatulence and improve lactation ability
Enlaibao/ tons, increasing the lactation yield of sows and the weaning litter size of piglets.
Features of Enlaibao (enramycin)
Production and quality assurance of Enlaibao
The company has established and improved the quality management system in strict accordance with the veterinary drug specifications of the Ministry of Agriculture, and strictly managed the production base
/> Internal control quality standards ensure the uniform, safe, effective and stable quality of active pharmaceutical ingredients
The product quality is stable and uniform, and the quality between batches is within the statistical confidence limit. Conduct product quality review and analysis every year to ensure that the process is stable and reliable and to detect adverse trends in a timely manner.
The stability of Enlaibao (enramycin) in feed
As a polypeptide antibiotic, degradation is the characteristic of enramycin itself. For this characteristic, research efforts are being made at home and abroad to solve it. After independent research and development, our company adopts unique and advanced production technology, which effectively prevents the degradation of product potency and has good stability.
Information about Enlaibao
Product specifications Each kilogram of Enlaibao contains two specifications: gram or gram of enramycin
Validity period: 1 month Packaging and storage Kilogram kraft paper bag, protected from light, sealed and stored in Dry place.
During the drug withdrawal period, precautions for drug withdrawal the day before slaughter are prohibited during the laying period
Instructions for enramycin premix
[Active ingredient] Enramycin
[Content specification] Each Contains enramycin or
[Applicable animals] pigs, chickens
[Appearance and properties] Brown or gray-brown powder with a special smell
[Pharmacology and effects] Gram-positive Bacteria have significant antibacterial effects, mainly hindering the synthesis of bacterial cell walls. Sensitive bacteria include Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus citrine, Streptococcus pyogenes, etc. Pneumococci, Bacillus subtilis, Bacillus anthracis, Clostridium tetani, Clostridium botulinum, and Clostridium perfringens are also susceptible.
[Action and use] Enramycin has strong activity against Gram-positive bacteria, especially harmful Clostridium in the intestine. Resistance is less likely to develop after long-term use. Used as a feed additive, it changes the bacterial population in the intestines, promotes weight gain in pigs and chickens, and improves feed efficiency.
【Usage and Dosage】Mixed feeding. Each feed added, pig~, chicken~, the above are all based on active ingredients.
[Packaging specifications] Composite paper bags are packed in kilograms per bag.
【Storage Method】Seal tightly and store in a dry place.
[Notes] It is forbidden to take medication during the laying period of laying hens.
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